• An Image Slideshow
  • An Image Slideshow
  • An Image Slideshow
  • An Image Slideshow

Publications (2008 onwards)

Publications in 2014:

 

Teoh SS, Vieusseux J, Prakash M, Berkowicz S, Luu J, Bird CH, Law RH, Rosado C, Price JT, Whisstock JC, Bird PI.

Maspin is not required for embryonic development or tumour suppression.

Nat Commun. 2014 Jan 20;5:3164. doi: 10.1038/ncomms4164.

 

Wang M, Zhao XM, Tan H, Akutsu T, Whisstock JC, Song J.

Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets.

Bioinformatics. 2014 Jan 1;30(1):71-80. doi: 10.1093/bioinformatics/btt603. Epub 2013 Oct 21.

 

 

Publications in 2013:

 

Pang SS, Nguyen ST, Perry AJ, Day CJ, Panjikar S, Tiralongo J, Whisstock JC, Kwok T.

Li SH, Reinke AA, Sanders KL, Emal CD, Whisstock JC, Stuckey JA, Lawrence DA.

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.

Proc Natl Acad Sci U S A. 2013 Dec 2. [Epub ahead of print]

 

Law RH, Abu-Ssaydeh D, Whisstock JC.

New insights into the structure and function of the plasminogen/plasmin system.

Curr Opin Struct Biol. 2013 Nov 16. doi:pii: S0959-440X(13)00182-6. 10.1016/j.sbi.2013.10.006. [Epub ahead of print]

 

Whisstock JC.

Assembling the machinery of coagulation.

Blood. 2013 Oct 17;122(16):2773-4. doi: 10.1182/blood-2013-08-516898.

  

Byrne H, Conroy PJ, Whisstock JC, O'Kennedy RJ.

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications.

Trends Biotechnol. 2013 Nov;31(11):621-32. doi: 10.1016/j.tibtech.2013.08.007. Epub 2013 Oct 2.

 

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I.

Defining the interaction of perforin with calcium and the phospholipid membrane. 

Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999.

 

Whisstock JC, Dunstone MA. 

Structural biology: Torqueing about pores.

Nat Chem Biol. 2013 Oct;9(10):605-6. doi: 10.1038/nchembio.1341.

 

Johnson TK, Crossman T, Foote KA, Henstridge MA, Saligari MJ, Forbes Beadle L, Herr A,Whisstock JC, Warr CG.

Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14688-92. doi: 10.1073/pnas.1309780110. Epub 2013 Aug 19.

 

Yongqing T, Wilmann PG, Reeve SB, Coetzer TH, Smith AI, Whisstock JC, Pike RN, Wijeyewickrema LC. 

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.

J Biol Chem. 2013 Aug 2;288(31):22399-407. doi: 10.1074/jbc.M113.483875.

 

Perry AJ, Wijeyewickrema LC, Wilmann PG, Gunzburg MJ, D'Andrea L, Irving JA, Pang SS, Duncan RC, Wilce JA, Whisstock JC, Pike RN.

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.

J Biol Chem. 2013 May 31;288(22):15821-9. doi: 10.1074/jbc.M113.464545. Epub 2013 Apr 16.

 

Yan XX, Porter CJ, Hardy SP, Steer D, Smith AI, Quinsey NS, Hughes V, Cheung JK, Keyburn AL, Kaldhusdal M, Moore RJ, Bannam TL, Whisstock JC, Rood JI.

Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens.

MBio. 2013 Feb 5;4(1):e00019-13. doi: 10.1128/mBio.00019-13.

 

Lopez JA, Susanto O, Jenkins MR, Lukoyanova N, Sutton VR, Law RH, Johnston A, Bird CH, Bird PI, Whisstock JC, Trapani JA, Saibil HR, Voskoboinik I.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Blood. 2013 Apr 4;121(14):2659-68. doi: 10.1182/blood-2012-07-446146. Epub 2013 Feb 1.

 

Langendorf CG, Tuck KL, Key TL, Fenalti G, Pike RN, Rosado CJ, Wong AS, Buckle AM, Law RH, Whisstock JC.

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates.

Biosci Rep. 2013 Jan 11;33(1):137-44. doi: 10.1042/BSR20120111. 

 

 

Publications in 2012:

 

Song J, Tan H, Perry AJ, Akutsu T, Webb GI, Whisstock JC, Pike RN.

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites.

PLoS One. 2012;7(11):e50300. doi: 10.1371/journal.pone.0050300. Epub 2012 Nov 29.

 

Han X, Kennan RM, Steer DL, Smith AI, Whisstock JC, Rood JI.

The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus.

PLoS One. 2012;7(10):e47932. doi: 10.1371/journal.pone.0047932. Epub 2012 Oct 24.

 

Teoh SS, Wang H, Risbridger GP, Whisstock JC, Bird PI.

A versatile monoclonal antibody specific to human SERPINB5.

Hybridoma (Larchmt). 2012 Oct;31(5):333-9. doi: 10.1089/hyb.2012.0035.

 

Lo JC, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, Field MC, Adams V, Ishikawa T, Aitken RJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK.

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

PLoS Genet. 2012;8(10):e1002969. doi: 10.1371/journal.pgen.1002969. Epub 2012 Oct 4.

 

Linke C, Siemens N, Oehmcke S, Radjainia M, Law RH, Whisstock JC, Baker EN, Kreikemeyer B.

The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module.

J Biol Chem. 2012 Nov 2;287(45):38178-89. doi: 10.1074/jbc.M112.376434. Epub 2012 Sep 12.

 

Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC.

The X-ray crystal structure of full-length human plasminogen.

Cell Rep. 2012 Mar 29;1(3):185-90. doi: 10.1016/j.celrep.2012.02.012. Epub 2012 Mar 8.

 

McGowan S, Buckle AM, Mitchell MS, Hoopes JT, Gallagher DT, Heselpoth RD, Shen Y, Reboul CF, Law RH, Fischetti VA, Whisstock JC, Nelson DC.

X-ray crystal structure of the streptococcal specific phage lysin PlyC.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12752-7. doi: 10.1073/pnas.1208424109. Epub 2012 Jul 17.

 

Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S.

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.

J Mol Biol. 2012 Sep 28;422(4):495-507. doi: 10.1016/j.jmb.2012.06.006. Epub 2012 Jun 16.

 

Orengo C, Whisstock J.

Structural insights into multi-protein communication systems.

Curr Opin Struct Biol. 2012 Jun;22(3):313-5. doi: 10.1016/j.sbi.2012.05.007. Epub 2012 Jun 1.

 

Lopez JA, Brennan AJ, Whisstock JC, Voskoboinik I, Trapani JA.

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death.

Trends Immunol. 2012 Aug;33(8):406-12. doi: 10.1016/j.it.2012.04.001. Epub 2012 May 18. Review.

 

D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi.

BMC Evol Biol. 2012 May 2;12:59. doi: 10.1186/1471-2148-12-59.

 

Reboul CF, Mahmood K, Whisstock JC, Dunstone MA.

Predicting giant transmembrane β-barrel architecture.

Bioinformatics. 2012 May 15;28(10):1299-302. doi: 10.1093/bioinformatics/bts152. Epub 2012 Mar 30.

 

Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M.

Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. 

PLoS One. 2012;7(2):e31938. doi: 10.1371/journal.pone.0031938. Epub 2012 Feb 16.

 

Mahmood K, Webb GI, Song J, Whisstock JC, Konagurthu AS.

Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs. 

Nucleic Acids Res. 2012 Mar;40(6):e44. doi: 10.1093/nar/gkr1261. Epub 2011 Dec 30.

 

Porter CJ, Bantwal R, Bannam TL, Rosado CJ, Pearce MC, Adams V, Lyras D, Whisstock JC, Rood JI.

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria. 

Mol Microbiol. 2012 Jan;83(2):275-88. doi: 10.1111/j.1365-2958.2011.07930.x. Epub 2011 Dec 11.

 

 

Publications in 2011:

 

Bird PI, Whisstock JC.

Serpin structure and evolution. Preface.

Methods Enzymol. 2011;501:xvii-xviii. doi: 10.1016/B978-0-12-385950-1.00026-2. 

 

Song J, Matthews AY, Reboul CF, Kaiserman D, Pike RN, Bird PI, Whisstock JC.

Predicting serpin/protease interactions.

Methods Enzymol. 2011;501:237-73. doi: 10.1016/B978-0-12-385950-1.00012-2. 

 

Dunstone MA, Whisstock JC.

Crystallography of serpins and serpin complexes.

Methods Enzymol. 2011;501:63-87. doi: 10.1016/B978-0-12-385950-1.00005-5.

 

Stivala A, Wybrow M, Wirth A, Whisstock JC, Stuckey PJ.

Automatic generation of protein structure cartoons with Pro-origami.

Bioinformatics. 2011 Dec 1;27(23):3315-6. doi: 10.1093/bioinformatics/btr575. Epub 2011 Oct 12.

 

Wong W, Wijeyewickrema LC, Kennan RM, Reeve SB, Steer DL, Reboul C, Smith AI, Pike RN, Rood JI, Whisstock JC, Porter CJ.

S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction.

J Biol Chem. 2011 Dec 9;286(49):42180-7. doi: 10.1074/jbc.M111.298711. Epub 2011 Oct 11.

 

Yamasaki M, Sendall TJ, Pearce MC, Whisstock JC, Huntington JA.

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.

EMBO Rep. 2011 Sep 30;12(10):1011-7. doi: 10.1038/embor.2011.171.

 

Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC.

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E526-34. doi: 10.1073/pnas.1105601108. Epub 2011 Aug 15.

 

Whisstock JC, Bird PI.

Biology of serpins. Preface.

Methods Enzymol. 2011;499:xix-xx. doi: 10.1016/B978-0-12-386471-0.00025-0.

 

Brennan AJ, Chia J, Browne KA, Ciccone A, Ellis S, Lopez JA, Susanto O, Verschoor S, Yagita H,Whisstock JC, Trapani JA, Voskoboinik I.

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Immunity. 2011 Jun 24;34(6):879-92. doi: 10.1016/j.immuni.2011.04.007. Epub 2011 Jun 9.

 

Alonzo F 3rd, Xayarath B, Whisstock JC, Freitag NE.

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence.

Mol Microbiol. 2011 Jun;80(6):1530-48. doi: 10.1111/j.1365-2958.2011.07665.x. Epub 2011 May 5.

 

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC.

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2.

 

Song J, Tan H, Boyd SE, Shen H, Mahmood K, Webb GI, Akutsu T, Whisstock JC, Pike RN.

Bioinformatic approaches for predicting substrates of proteases.

J Bioinform Comput Biol. 2011 Feb;9(1):149-78. Review.

 

  

Publications in 2010:

 

Kennan RM, Wong W, Dhungyel OP, Han X, Wong D, Parker D, Rosado CJ, Law RH, McGowan S, Reeve SB, Levina V, Powers GA, Pike RN, Bottomley SP, Smith AI, Marsh I, Whittington RJ,Whisstock JC, Porter CJ, Rood JI.

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates.

PLoS Pathog. 2010 Nov 24;6(11):e1001210. doi: 10.1371/journal.ppat.1001210.

 

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC.

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31.

 

Kondos SC, Hatfaludi T, Voskoboinik I, Trapani JA, Law RH, Whisstock JC, Dunstone MA.

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

Tissue Antigens. 2010 Nov;76(5):341-51. doi: 10.1111/j.1399-0039.2010.01566.x. Epub 2010 Sep 22. Review.

 

Huntington JA, Whisstock JC.

Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers.

Biol Chem. 2010 Aug;391(8):973-82. doi: 10.1515/BC.2010.085.

 

Pike RN, Whisstock JC.

Highlight: the biology of proteolytic systems.

Biol Chem. 2010 Aug;391(8):837. doi: 10.1515/BC.2010.112.

 

Mahmood K, Konagurthu AS, Song J, Buckle AM, Webb GI, Whisstock JC.

EGM: encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes.

Bioinformatics. 2010 Sep 1;26(17):2076-84. doi: 10.1093/bioinformatics/btq339. Epub 2010 Jun 27.

 

Voskoboinik I, Dunstone MA, Baran K, Whisstock JC, Trapani JA.

Perforin: structure, function, and role in human immunopathology.

Immunol Rev. 2010 May;235(1):35-54. doi: 10.1111/j.0105-2896.2010.00896.x. Review.

 

Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI.

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.

J Biol Chem. 2010 Aug 6;285(32):24299-305. doi: 10.1074/jbc.R110.112771. Epub 2010 May 24. Review. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740.

 

Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA.

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.

J Biol Chem. 2010 Aug 6;285(32):24307-12. doi: 10.1074/jbc.R110.141408. Epub 2010 May 24. Review.

 

Newton HJ, Pearson JS, Badea L, Kelly M, Lucas M, Holloway G, Wagstaff KM, Dunstone MA, Sloan J, Whisstock JC, Kaper JB, Robins-Browne RM, Jans DA, Frankel G, Phillips AD, Coulson BS, Hartland EL.

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

PLoS Pathog. 2010 May 13;6(5):e1000898. doi: 10.1371/journal.ppat.1000898. 

 

Schmidberger JW, Bate MA, Reboul CF, Androulakis SG, Phan JM, Whisstock JC, Goscinski WJ, Abramson D, Buckle AM.

MrGrid: a portable grid based molecular replacement pipeline.

PLoS One. 2010 Apr 6;5(4):e10049. doi: 10.1371/journal.pone.0010049.

 

Konagurthu AS, Reboul CF, Schmidberger JW, Irving JA, Lesk AM, Stuckey PJ, Whisstock JC, Buckle AM.

MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography.

PLoS One. 2010 Apr 6;5(4):e10048. doi: 10.1371/journal.pone.0010048.

 

Wong W, Kennan RM, Rosado CJ, Rood JI, Whisstock JC, Porter CJ.

Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):289-93. doi: 10.1107/S1744309110000333. Epub 2010 Feb 24.

 

Langendorf CG, Key TL, Fenalti G, Kan WT, Buckle AM, Caradoc-Davies T, Tuck KL, Law RH,Whisstock JC.

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.

PLoS One. 2010 Feb 18;5(2):e9280. doi: 10.1371/journal.pone.0009280.

 

McGowan S, Oellig CA, Birru WA, Caradoc-Davies TT, Stack CM, Lowther J, Skinner-Adams T, Mucha A, Kafarski P, Grembecka J, Trenholme KR, Buckle AM, Gardiner DL, Dalton JP,Whisstock JC.

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2449-54. doi: 10.1073/pnas.0911813107. Epub 2010 Jan 21.

 

Song J, Tan H, Shen H, Mahmood K, Boyd SE, Webb GI, Akutsu T, Whisstock JC.

Cascleave: towards more accurate prediction of caspase substrate cleavage sites.

Bioinformatics. 2010 Mar 15;26(6):752-60. doi: 10.1093/bioinformatics/btq043. Epub 2010 Feb 3.

 

Teoh SS, Whisstock JC, Bird PI.

Maspin (SERPINB5) is an obligate intracellular serpin.

J Biol Chem. 2010 Apr 2;285(14):10862-9. doi: 10.1074/jbc.M109.073171. Epub 2010 Feb 1.

 

Skinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, Mucha A, Drag M, Kafarski P, McGowan S, Whisstock JC, Gardiner DL, Dalton JP.

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.

Trends Biochem Sci. 2010 Jan;35(1):53-61. doi: 10.1016/j.tibs.2009.08.004. Epub 2009 Sep 30. Review.

 

 

Publications in 2009:

 

Arafat Y, Fenalti G, Whisstock JC, Mackay IR, Garcia de la Banda M, Rowley MJ, Buckle AM.

Structural determinants of GAD antigenicity.

Mol Immunol. 2009 Dec;47(2-3):493-505. doi: 10.1016/j.molimm.2009.08.022. Epub 2009 Sep 23.

 

Song J, Tan H, Mahmood K, Law RH, Buckle AM, Webb GI, Akutsu T, Whisstock JC.

Prodepth: predict residue depth by support vector regression approach from protein sequences only.

PLoS One. 2009 Sep 17;4(9):e7072. doi: 10.1371/journal.pone.0007072.

 

Murray-Rust TA, Kerr FK, Thomas AR, Wu T, Yongqing T, Ong PC, Quinsey NS, Whisstock JC, Wagenaar-Bos IC, Freeman C, Pike RN.

Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1.

Biochem J. 2009 Aug 13;422(2):295-303. doi: 10.1042/BJ20090198.

 

Chia J, Yeo KP, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I.

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. 

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9809-14. doi: 10.1073/pnas.0903815106. Epub 2009 Jun 1.

 

Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H,Whisstock JC, Voskoboinik I, Trapani JA.

The molecular basis for perforin oligomerization and transmembrane pore assembly. 

Immunity. 2009 May;30(5):684-95. doi: 10.1016/j.immuni.2009.03.016. Epub 2009 May 14.

 

Fischer K, Langendorf CG, Irving JA, Reynolds S, Willis C, Beckham S, Law RH, Yang S, Bashtannyk-Puhalovich TA, McGowan S, Whisstock JC, Pike RN, Kemp DJ, Buckle AM.

Structural mechanisms of inactivation in scabies mite serine protease paralogues.

J Mol Biol. 2009 Jul 24;390(4):635-45. doi: 10.1016/j.jmb.2009.04.082. Epub 2009 May 7.

 

Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI.

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5587-92. doi: 10.1073/pnas.0811968106. Epub 2009 Mar 19.

 

Ong PC, Golding SJ, Pearce MC, Irving JA, Grigoryev SA, Pike D, Langendorf CG, Bashtannyk-Puhalovich TA, Bottomley SP, Whisstock JC, Pike RN, McGowan S.

Conformational change in the chromatin remodelling protein MENT.

PLoS One. 2009;4(3):e4727. doi: 10.1371/journal.pone.0004727. Epub 2009 Mar 6.

 

McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL,Whisstock JC, Dalton JP.

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2537-42. doi: 10.1073/pnas.0807398106. Epub 2009 Feb 5.

 

 

 

Publications in 2008:

 

Whisstock JC, Bottomley SP.

Structural biology: Serpins' mystery solved. 

Nature. 2008 Oct 30;455(7217):1189-90. doi: 10.1038/4551189a.

 

Androulakis S, Schmidberger J, Bate MA, DeGori R, Beitz A, Keong C, Cameron B, McGowan S, Porter CJ, Harrison A, Hunter J, Martin JL, Kobe B, Dobson RC, Parker MW, Whisstock JC, Gray J, Treloar A, Groenewegen D, Dickson N, Buckle AM.

Federated repositories of X-ray diffraction images. 

Acta Crystallogr D Biol Crystallogr. 2008 Jul;D64(Pt 7):810-4. doi: 10.1107/S0907444908015540. Epub 2008 Jun 18.

 

Rosado CJ, Kondos S, Bull TE, Kuiper MJ, Law RH, Buckle AM, Voskoboinik I, Bird PI, Trapani JA,Whisstock JC, Dunstone MA.

The MACPF/CDC family of pore-forming toxins. 

Cell Microbiol. 2008 Sep;10(9):1765-74. doi: 10.1111/j.1462-5822.2008.01191.x. Epub 2008 Jun 28. Review.

 

Steenbakkers PJ, Irving JA, Harhangi HR, Swinkels WJ, Akhmanova A, Dijkerman R, Jetten MS, van der Drift C, Whisstock JC, Op den Camp HJ.

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

Mycol Res. 2008 Aug;112(Pt 8):999-1006. doi: 10.1016/j.mycres.2008.01.021. Epub 2008 Feb 16.

 

Schmidberger JW, Wilce JA, Weightman AJ, Whisstock JC, Wilce MC.

The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism.

J Mol Biol. 2008 Apr 18;378(1):284-94. doi: 10.1016/j.jmb.2008.02.035. Epub 2008 Feb 29.

 

Zhang Q, Law RH, Bottomley SP, Whisstock JC, Buckle AM.

A structural basis for loop C-sheet polymerization in serpins.

J Mol Biol. 2008 Mar 7;376(5):1348-59. doi: 10.1016/j.jmb.2007.12.050. Epub 2008 Jan 3.

 

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ.

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

Diabetes. 2008 May;57(5):1293-301. doi: 10.2337/db07-1461. Epub 2008 Jan 9.

 

Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB.

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin.

Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6.