The Whisstock Laboratory
The Whisstock laboratory focuses upon the structure, function and biology of medically important proteins. We are particularly interested in proteases, protease inhibitors and the perforin-like superfamily of pore forming toxins.
From a disease perspective our team focuses on infection, immunity, coagulation, fibrinolysis and cancer.
The Whisstock laboratory largely studies immune defence and blood coagulation and how these processes relate to cancer, inflammatory diseases and coagulation disorders.
Recent outcomes from our laboratory include the structures of the immune effector perforin and the zymogen form of the fibrinolytic protease plasmin.
Techniques in use in the laboratory include Structural Biology (X-ray crystallography), bioinformatics, biochemistry / enzymology, drug development and molecular cell biology.
We also utilise Mouse and Drosophila model organisms in our research.
The laboratory is supported through recent grants from the Australian Research Council, the National Health and Medical Research Council, the Wellcome Trust and the Trans Tasman Commercialisation Fund.
The laboratory includes senior scientists with expertise in a wide range of different disciplines.